Chemistry Related to Biology and Medicine

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Published Feb 25, 2023
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Vol. 2 No. 01 (2023): February

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Wali Imam Ulfat
Mati Ur Rehman Yousafzai
Mohammad Agha Dadman
Ziaulhaq Azizi
Khudaidad Kochia

Abstract

Reviewing several facets of Fenton Chemistry's involvement in biology and medicine. There is growing indication that a number of Fenton and Fenton-like reactions can result in the formation of both the OH radical and ferryl . There are a few examples of hydroxyl radical generation that is unrelated to metals. The wood-decaying fungus that causes white rot and brown rot serve as examples of extracellular Fenton reactions. Numerous studies have been published in this area ever since Fenton chemistry and biomedicine were initially linked. Understanding and advancing this topic would be aided by a thorough exposition of the principles of Fenton chemistry and a synopsis of its representative applications in cancer therapy. The current state of Fenton chemistry is then examined, and a few pertinent illustrative instances are provided. Additionally, the current methods for further improving the efficacy of chemotherapy dynamic therapy under the direction of Fenton chemistry are highlighted. The combination of biomedicine and Fenton chemistry or a larger range of catalytic chemistry techniques is given with future possibilities being especially significant. Recently developed reactive oxygen species (ROS) engineered nano catalytic medicines in cancer therapy based on the Fenton reaction, defined as chemical dynamic therapy (CDT), have been extensively studied and made rapid progress. However, the complexity and heterogeneity of tumors reduce the Fenton reaction's ability to oxidize molecules effectively. To increase the effectiveness of CDT and conventional therapeutic approaches, numerous modified tactics, including the Fenton-like reaction and other reactions, are being investigated. This study highlights current developments in the development and use of Fenton nanocatalysts that use the Fenton or modified Fenton reaction for CDT. Also highlighted is the catechol-driven Fenton reaction's natural and useful use.

Keywords

Reactive O2 Species, Redox Cycling, Oxidative Stress, Free Radicals, Carcinogenesis, Fenton Reaction and Chemo Dynamic Therapy

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How to Cite
Ulfat, W. I., Yousafzai, M. U. R., Dadman, M. A., Azizi, Z., & Kochia, K. (2023). Chemistry Related to Biology and Medicine. NUIJB, 2(01), 104–116. Retrieved from https://nuijb.nu.edu.af/index.php/nuijb/article/view/27

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